Melanoma

Introduction to Melanoma

Melanoma is a serious form of skin cancer that can develop in anyone. When caught early, it’s highly treatable, with cure rates close to 100%. However, because melanoma can spread to other parts of the body, it is considered the deadliest type of skin cancer. Anyone can get melanoma.

Why Does Melanoma Occur?

The most significant risk factor for melanoma is exposure to ultraviolet (UV) light, whether from the sun or tanning beds. However, not all melanomas are caused by UV exposure. Genetics also play a crucial role, and having a close relative with melanoma increases your risk.

Certain factors can elevate your risk of developing melanoma:

  • Light skin, hair, and eyes.
  • Skin that burns easily or doesn’t tan well.
  • A high number of moles, especially unusual ones.
  • A history of severe sunburns, particularly in childhood.
  • Personal or family history of melanoma.
  • Regular use of indoor tanning beds.
  • A compromised immune system.

Melanoma in Skin of Color

While melanoma is less common in individuals with darker skin, it often appears in areas not usually exposed to the sun, such as the bottoms of the feet, palms, inside the mouth, and under the nails. Regular checks of these areas are crucial for early detection.

Spotting Melanoma

Early detection of melanoma significantly increases the chances of successful treatment. Use the “ABCDE” rule to remember the warning signs:

  • Asymmetry: One half doesn’t match the other.
  • Border: Edges are irregular or blurred.
  • Color: Uneven shades of brown, black, or other colors.
  • Diameter: Larger than 6mm (the size of a pencil eraser), though melanomas can be smaller.
  • Evolving: Changes in size, shape, or color over time.

Regular Self-Checks

  1. Examine your entire body in a full-length mirror, including front, back, and sides.
  2. Bend elbows and closely inspect forearms, upper arms, and palms.
  3. Look at the backs of your legs, between your toes, and the soles of your feet.
  4. Use a hand mirror to check the back of your neck and scalp.
  5. Don’t forget your back and buttocks.

If you notice anything suspicious, a dermatologist will perform a skin biopsy, removing part or all of the growth to check for cancerous cells under a microscope. This is the only way to confirm if it’s melanoma.

Treatment Options

  • Excision: Surgical removal of the melanoma and some surrounding tissue.
  • Mohs Surgery: A specialized procedure where the cancer is removed layer by layer and examined until no cancer cells remain.

For more advanced melanoma, treatment options may include immunotherapy, targeted therapy, radiation, or chemotherapy.

Preventing Melanoma

Protecting your skin from UV exposure is key to preventing melanoma:

  • Seek shade during peak sun hours (10 a.m. to 2 p.m.).
  • Wear protective clothing, including a wide-brimmed hat and UV-blocking sunglasses.
  • Use a broad-spectrum sunscreen with SPF 30 or higher on all exposed skin, and reapply every two hours or after swimming/sweating.
  • Avoid tanning beds, which emit harmful UV rays.
  • Perform regular skin self-exams and see a dermatologist for any changes.

Frequently Asked Questions About Melanoma

What is melanoma?

Melanoma is the most serious form of skin cancer, arising from melanocytes — the cells that produce pigment. While it accounts for a smaller proportion of skin cancers than basal cell or squamous cell carcinoma, melanoma is responsible for the majority of skin cancer deaths due to its ability to spread to other organs. When caught early, melanoma is highly treatable, with cure rates close to 100% for thin, localized tumors.

What does melanoma look like?

Dermatologists use the ABCDE rule to identify suspicious moles: Asymmetry (one half doesn’t match the other), Border irregularity (ragged, notched, or blurred edges), Color variation (multiple shades of brown, black, red, white, or blue), Diameter greater than 6mm (about the size of a pencil eraser), and Evolution (any change in size, shape, color, or a new symptom like bleeding or itching). Any mole or lesion that changes rapidly should be evaluated immediately.

What are the risk factors for melanoma?

Key risk factors include a history of sunburns (especially blistering burns in childhood), excessive UV exposure or tanning bed use, fair skin and light eyes, a personal or family history of melanoma, a large number of moles or atypical moles, and certain genetic mutations. However, melanoma can develop in anyone — including people with darker skin tones, often in less sun-exposed areas.

How is melanoma treated?

Melanoma treatment depends on stage. Early, thin melanomas are treated with surgical excision with appropriate margins — the primary and most important treatment. More advanced melanomas may require sentinel lymph node biopsy, immunotherapy, targeted therapy, or radiation. Early detection dramatically improves outcomes, which is why regular skin checks are critical for high-risk patients.

How is melanoma different from a regular mole?

Ordinary moles are typically round or oval, uniformly colored, have smooth borders, and remain stable over time. Melanomas tend to be asymmetric, have irregular or uneven borders, show multiple colors, grow larger than 6mm, and change over time. If you notice any mole that looks different from your others (‘ugly duckling sign’) or that has changed recently, see a dermatologist promptly.

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Dr. Jane Yoo Board-Certified Dermatologist and Mohs Surgeon
Jane Yoo, MD, MPP, is a Korean American board-certified dermatologist and fellowship-trained Mohs surgeon based in Midtown Manhattan. She is a Clinical Assistant Professor at the Icahn School of Medicine at Mount Sinai and the founder of Jane Yoo MD, PLLC and the Clinical Research Center of New York. Dr. Yoo holds an undergraduate degree from MIT and a Masters of Public Policy from Harvard's Kennedy School of Government. She completed her Mohs micrographic surgery fellowship at Yale. Her clinical and research focus spans aesthetic clinical trials including injectables and laser technology, skincare formulation and sunscreen science, K-Beauty and skin of color, ultrasound guided filler dissolution, artificial intelligence and beauty tech. Dr. Yoo's research is indexed under ORCID 0000-0002-7112-8963.