Beta-Glucan in Skincare: What It Does and Who It’s For 

Beta-glucan doesn’t have the viral name recognition of snail mucin or centella asiatica, but it’s quietly become one of the more clinically interesting ingredients showing up in Korean moisturizers and serums,  and it’s one I actually recommend for a specific group of patients: those with compromised or reactive barriers, including some eczema prone skin. 

What Beta-Glucan Actually Is 

Beta-glucan is a polysaccharide derived from sources like oats, yeast, or mushrooms. In skincare, it’s most commonly sourced from oats (the same barrier-supportive category as colloidal oatmeal, a long-standing dermatologist recommendation for dry and eczema-prone skin). 

What the Evidence Supports 

  • Barrier repair and hydration, functioning as both a humectant and a film-forming agent that helps reduce transepidermal water loss
  • Soothing, anti-irritant properties, which is why it’s often paired with centella asiatica or panthenol in barrier-focused formula
  • Some evidence for skin healing support, consistent with its traditional use in wound-care contexts 

Its profile has genuine overlap with why dermatologists have long recommended oat-based products for eczema and sensitive skin. Beta-glucan is essentially a more concentrated, cosmetically elegant delivery of that same barrier-supportive mechanism. 

Who Should Consider It 

  • Eczema-prone or chronically dry skin, as a barrier-support layer alongside (not instead of) prescribed treatments
  • Post-procedure or post-retinoid skin, where barrier repair is the priority
  • Reactive, easily irritated skin looking for a gentler alternative to more aggressive actives 

Beta-Glucan vs. Ceramides: Do You Need Both? 

Beta-glucan and ceramides work through complementary mechanisms. Ceramides physically replace lipid “mortar” in the skin barrier, while beta-glucan primarily hydrates and forms a protective film. Many well-formulated K-beauty moisturizers include both, and there’s no conflict in using them together; they’re not redundant. 

Frequently Asked Questions 

Is beta-glucan good for eczema?

It can be a helpful supportive, barrier-repair ingredient for eczema-prone skin, but it should complement rather than replace any prescribed treatment plan from your dermatologist. 

Can beta-glucan cause breakouts? 

It’s generally considered non comedogenic and well-tolerated, including for oily or acne-prone skin. 

Is beta-glucan the same as oat extract? 

Beta-glucan is the specific active polysaccharide found in oats (and other sources like yeast); “oat extract” is a broader term that may or may not be standardized to a specific beta-glucan concentration. 

How do I know if a product has enough beta-glucan to work? 

Ingredient lists don’t always disclose concentration, so look for products that lead with beta-glucan prominently in their marketing and ingredient order, rather than a formula where it’s listed near the very end. 

 

Updated July 2026

author avatar
Dr. Jane Yoo Board-Certified Dermatologist and Mohs Surgeon
Jane Yoo, MD, MPP, is a Korean American board-certified dermatologist and fellowship-trained Mohs surgeon based in Midtown Manhattan. She is a Clinical Assistant Professor at the Icahn School of Medicine at Mount Sinai and the founder of Jane Yoo MD, PLLC and the Clinical Research Center of New York. Dr. Yoo holds an undergraduate degree from MIT and a Masters of Public Policy from Harvard's Kennedy School of Government. She completed her Mohs micrographic surgery fellowship at Yale. Her clinical and research focus spans aesthetic clinical trials including injectables and laser technology, skincare formulation and sunscreen science, K-Beauty and skin of color, ultrasound guided filler dissolution, artificial intelligence and beauty tech. Dr. Yoo's research is indexed under ORCID 0000-0002-7112-8963.