Evolysse Smooth: Advanced Hyaluronic Acid FillerEmpty heading

Evolysse is a new collection of injectable hyaluronic acid (HA) fillers designed to enhance facial volume, smooth wrinkles, and provide long-lasting rejuvenation. Developed by Evolus in partnership with Symatese, these fillers utilize Cold-X Technology, an advanced formulation process that preserves HA’s natural structure for improved lift, flexibility, and durability.

The first two FDA-approved products in the Evolysse line, Evolysse Form and Evolysse Smooth, are designed to treat moderate to severe facial wrinkles and volume loss while ensuring natural-looking, long-lasting results.

Evolysse fillers are engineered to deliver a balance between smooth integration, natural movement, and structural support. Unlike traditional HA fillers, Cold-X Technology optimizes the viscoelastic properties of HA, allowing for better adaptability in facial tissues.

Key benefits of Evolysse include:

  • Advanced HA structure for seamless integration and tissue compatibility
  • Natural movement and flexibility, reducing stiffness in treated areas
  • Long-lasting results, with clinical trials showing effects for up to 12 months
  • Minimal swelling and downtime, allowing for quick recovery

Evolysse was designed to offer customized treatment options, ensuring that patients receive the most effective filler for their individual facial anatomy and aesthetic goals.

Evolysse Smooth is a softer, more flexible HA filler designed for delicate wrinkle correction and seamless blending with natural facial movements. It is formulated for areas where subtle refinement and smooth integration are essential, ensuring a soft, natural look.

This filler is best suited for individuals who want to:

  • Reduce moderate wrinkles and fine lines while maintaining facial expressiveness
  • Enhance hydration and skin quality, improving overall texture
  • Smooth dynamic facial areas, such as around the mouth and lips
  • Provide a refreshed appearance without excessive volume or stiffness

Because of its smooth, adaptable consistency, Evolysse Smooth integrates effortlessly into the skin, making it ideal for patients who want refined but noticeable improvements in facial appearance. Like Evolysse Form, it has been clinically tested to last up to 12 months, offering long-term results with minimal downtime.

Evolysse Smooth is formulated using Cold-X Technology, an advanced process that protects HA’s natural structure through near-freezing manufacturing conditions. This allows the filler to retain its elasticity and fluidity for optimal blending within facial tissues.

Key benefits of Cold-X Technology include:

  • Preserves HA structure for a smoother, more natural feel
  • Reduces the risk of swelling or stiffness post-treatment
  • Enhances hydration and skin quality through improved HA integrity
  • Promotes gentle tissue integration for refined, natural-looking results
  • What Makes Evolysse Smooth Different

Evolysse Smooth was created for areas that demand subtle correction and soft tissue flexibility. Its smooth, adaptable consistency allows it to move naturally with facial expressions, ensuring results that look refreshed but never overdone. Clinical studies demonstrated that Evolysse Smooth achieved statistically superior wrinkle reduction compared to a leading HA filler, while using approximately 20% less product.

Key advantages of Evolysse Smooth include:

  • Soft, cohesive gel ideal for fine to moderate wrinkles
  • Smooth integration for natural expression and texture
  • Long-lasting results for up to 12 months
  • Quick recovery with minimal downtime
  • High satisfaction among patients seeking gentle yet noticeable enhancement

Mechanism of action:

  • Smooths moderate wrinkles and lines such as nasolabial folds
  • Enhances hydration and elasticity for softer, more luminous skin
  • Refines dynamic facial areas like the mouth and perioral region
  • Restores balance without adding excessive volume

Treatment Areas

Evolysse Smooth is ideal for patients who want natural refinement and improvement in facial texture. It is most often used in:

  • Moderate facial wrinkles, including nasolabial folds and smile lines
  • Fine lines around the mouth and lips
  • Areas requiring soft tissue blending or flexibility
  • Patients desiring subtle correction rather than volumizing lift

Clinical Results and Longevity

In U.S. pivotal clinical trials, Evolysse Smooth achieved consistent, long-lasting results with excellent safety and tolerability.

Study outcomes included:

  • Statistical superiority to the control filler at six months
  • 20% less product volume needed for equivalent correction
  • High satisfaction, with over 90% of participants reporting improvement
  • Sustained correction through 12 months in most patients
  • Minimal side effects, such as mild tenderness or swelling resolving within one week

Ideal Candidates

Evolysse Smooth is best suited for individuals seeking subtle, natural facial rejuvenation. It is ideal for those who:

  • Want to soften moderate wrinkles and fine lines
  • Prefer natural expressiveness without added bulk
  • Seek smooth integration with dynamic facial movement
  • Desire refreshed, hydrated, and youthful skin texture
  • Prefer a non-surgical, low-downtime solution

The Future of HA Fillers with Evolysse

Evolysse represents a new era in HA filler technology, combining scientific innovation with aesthetic precision. Its Cold-X Technology sets a new standard for HA filler performance, longevity, and patient satisfaction, making it a valuable addition to non-surgical aesthetic treatments.

With the ability to customize treatment based on individual needs, Evolysse is paving the way for more refined, natural-looking results in facial aesthetics.