Evolysse Form: Advanced Hyaluronic Acid FillerEmpty heading

Evolysse is a new collection of injectable hyaluronic acid (HA) fillers designed to enhance facial volume, smooth wrinkles, and provide long-lasting rejuvenation. Developed by Evolus in partnership with Symatese, these fillers utilize Cold-X Technology, an advanced formulation process that preserves HA’s natural structure for improved lift, flexibility, and durability.

The first two FDA-approved products in the Evolysse line, Evolysse Form and Evolysse Smooth, are designed to treat moderate to severe facial wrinkles and volume loss while ensuring natural-looking, long-lasting results.

Evolysse fillers are engineered to deliver a balance between smooth integration, natural movement, and structural support. Unlike traditional HA fillers, Cold-X Technology optimizes the viscoelastic properties of HA, allowing for better adaptability in facial tissues.

Key benefits of Evolysse include:

  • Advanced HA structure for seamless integration and tissue compatibility
  • Natural movement and flexibility, reducing stiffness in treated areas
  • Long-lasting results, with clinical trials showing effects for up to 12 months
  • Minimal swelling and downtime, allowing for quick recovery

Evolysse was designed to offer customized treatment options, ensuring that patients receive the most effective filler for their individual facial anatomy and aesthetic goals.

Evolysse Form is a firm, high-density HA filler created for deep-set wrinkles, volume restoration, and facial contouring. It provides enhanced structural support, making it particularly effective in areas that require significant lifting power.

This filler is ideal for patients with noticeable volume loss or deep facial folds who want a long-lasting, non-surgical solution for facial rejuvenation. It can be used to:

  • Restore volume in the cheeks and midface, addressing age-related volume depletion
  • Define facial contours, particularly along the jawline and chin
  • Smooth deep wrinkles and folds, including nasolabial folds and marionette lines
  • Improve overall facial symmetry, creating a more youthful and balanced appearance

Evolysse Form is injected into the deeper layers of the skin, where it integrates with the tissue to provide natural-looking lift and structure. Clinical trials have demonstrated that its effects last up to 12 months, with high levels of patient satisfaction.

Cold-X Technology sets Evolysse apart from traditional HA fillers. Instead of using heat, which can break down and weaken HA chains, this process uses near-freezing temperatures to preserve the molecule’s natural integrity.

Key benefits of Cold-X Technology include:

  • Maintains HA’s natural structure for optimal tissue compatibility
  • Produces a smooth, cohesive gel with enhanced flexibility
  • Reduces risk of swelling and improves recovery time
  • Delivers natural lift and contour while maintaining facial movement

Clinical studies highlight the following advantages:

  • Proven improvement in deep facial wrinkles and folds
  • Statistically superior results compared to a leading HA filler at six months
  • Visible effects lasting up to 12 months in most patients
  • High satisfaction rates, with over 90% of patients reporting positive outcomes
  • Minimal downtime with quick return to daily activities

Mechanism of action:

  • Adds structural lift to restore youthful contours
  • Fills and smooths deep wrinkles such as nasolabial folds
  • Supports the midface and jawline for improved definition
  • Includes lidocaine for greater comfort during injection

Treatment Areas

Evolysse Form is ideal for areas that require lift and structural reinforcement, including:

  • Deep wrinkles and folds (nasolabial folds, marionette lines)
  • Midface and cheek volume loss
  • Chin and jawline contouring
  • Facial areas affected by significant age-related volume depletion

Clinical Results and Longevity

Evolysse Form underwent a U.S. pivotal clinical trial that compared it with a control HA filler. Results showed:

  • Superior wrinkle reduction at multiple time points
  • Long-lasting correction maintained through 12 months in 72% of participants
  • High satisfaction, with 80% rating their appearance as improved at one year
  • Minimal downtime, with mild side effects resolving within one week
  • Consistent safety, with no delayed-onset nodules or serious complications reported

Ideal Candidates

Evolysse Form is recommended for individuals who want visible yet natural correction of deep wrinkles and volume loss. Ideal candidates typically:

  • Have moderate to severe facial wrinkles or folds
  • Want to restore lost cheek or midface volume
  • Desire defined contouring along the jawline or chin
  • Prefer a non-surgical option that offers structure and durability
  • Seek results that look natural at rest and in motion

The Future of HA Fillers with Evolysse

Evolysse represents a new era in HA filler technology, combining scientific innovation with aesthetic precision. Its Cold-X Technology sets a new standard for HA filler performance, longevity, and patient satisfaction, making it a valuable addition to non-surgical aesthetic treatments.

With the ability to customize treatment based on individual needs, Evolysse is paving the way for more refined, natural-looking results in facial aesthetics.